diff --git a/internal/uidriver/glfw/ui.go b/internal/uidriver/glfw/ui.go
index e4d780c93..3827dbf17 100644
--- a/internal/uidriver/glfw/ui.go
+++ b/internal/uidriver/glfw/ui.go
@@ -520,6 +520,10 @@ func (u *UserInterface) SetFullscreen(fullscreen bool) {
 	}
 
 	_ = u.t.Call(func() error {
+		if u.isNativeFullscreen() {
+			return nil
+		}
+
 		w, h := u.windowWidth, u.windowHeight
 		u.setWindowSize(w, h, fullscreen)
 		return nil
diff --git a/internal/uidriver/glfw/ui_darwin.go b/internal/uidriver/glfw/ui_darwin.go
index 3196c835d..e7c60dafb 100644
--- a/internal/uidriver/glfw/ui_darwin.go
+++ b/internal/uidriver/glfw/ui_darwin.go
@@ -38,6 +38,11 @@ package glfw
 //   *x = bounds.origin.x;
 //   *y = bounds.origin.y;
 // }
+//
+// static bool isNativeFullscreen() {
+//   return [[NSApplication sharedApplication] currentSystemPresentationOptions] &
+//       NSApplicationPresentationFullScreen;
+// }
 import "C"
 
 import (
@@ -82,3 +87,7 @@ func currentMonitorByOS(w *glfw.Window) *glfw.Monitor {
 func (u *UserInterface) nativeWindow() uintptr {
 	return u.window.GetCocoaWindow()
 }
+
+func (u *UserInterface) isNativeFullscreen() bool {
+	return bool(C.isNativeFullscreen())
+}
diff --git a/internal/uidriver/glfw/ui_unix.go b/internal/uidriver/glfw/ui_unix.go
index 69c8a2d82..22ae847c4 100644
--- a/internal/uidriver/glfw/ui_unix.go
+++ b/internal/uidriver/glfw/ui_unix.go
@@ -63,3 +63,7 @@ func (u *UserInterface) nativeWindow() uintptr {
 	// TODO: Implement this.
 	return 0
 }
+
+func (u *UserInterface) isNativeFullscreen() bool {
+	return false
+}
diff --git a/internal/uidriver/glfw/ui_windows.go b/internal/uidriver/glfw/ui_windows.go
index c2e7b12bb..b15c8df6e 100644
--- a/internal/uidriver/glfw/ui_windows.go
+++ b/internal/uidriver/glfw/ui_windows.go
@@ -145,3 +145,7 @@ func currentMonitorByOS(w *glfw.Window) *glfw.Monitor {
 func (u *UserInterface) nativeWindow() uintptr {
 	return u.window.GetWin32Window()
 }
+
+func (u *UserInterface) isNativeFullscreen() bool {
+	return false
+}
diff --git a/internal/uidriver/glfw/window.go b/internal/uidriver/glfw/window.go
index c53575f11..8a3c5d8eb 100644
--- a/internal/uidriver/glfw/window.go
+++ b/internal/uidriver/glfw/window.go
@@ -47,6 +47,10 @@ func (w *window) SetDecorated(decorated bool) {
 	}
 
 	_ = w.ui.t.Call(func() error {
+		if w.ui.isNativeFullscreen() {
+			return nil
+		}
+
 		v := glfw.False
 		if decorated {
 			v = glfw.True
@@ -79,6 +83,10 @@ func (w *window) SetResizable(resizable bool) {
 		return
 	}
 	_ = w.ui.t.Call(func() error {
+		if w.ui.isNativeFullscreen() {
+			return nil
+		}
+
 		v := glfw.False
 		if resizable {
 			v = glfw.True
@@ -106,6 +114,10 @@ func (w *window) SetFloating(floating bool) {
 		return
 	}
 	_ = w.ui.t.Call(func() error {
+		if w.ui.isNativeFullscreen() {
+			return nil
+		}
+
 		v := glfw.False
 		if floating {
 			v = glfw.True
diff --git a/run.go b/run.go
index 2a6f1476a..8afc618e3 100644
--- a/run.go
+++ b/run.go
@@ -270,6 +270,9 @@ func IsFullscreen() bool {
 //
 // SetFullscreen does nothing on browsers or mobiles.
 //
+// SetFullscreen does nothing on macOS when the window is fullscreened natively by the macOS desktop
+// instead of SetFullscreen(true).
+//
 // SetFullscreen is concurrent-safe.
 func SetFullscreen(fullscreen bool) {
 	uiDriver().SetFullscreen(fullscreen)
diff --git a/window.go b/window.go
index c89373a08..d80b28cdf 100644
--- a/window.go
+++ b/window.go
@@ -42,6 +42,9 @@ func IsWindowDecorated() bool {
 // SetWindowDecorated works only on desktops.
 // SetWindowDecorated does nothing on other platforms.
 //
+// SetWindowDecorated does nothing on macOS when the window is fullscreened natively by the macOS desktop
+// instead of SetFullscreen(true).
+//
 // SetWindowDecorated is concurrent-safe.
 func SetWindowDecorated(decorated bool) {
 	if w := uiDriver().Window(); w != nil {
@@ -67,6 +70,9 @@ func IsWindowResizable() bool {
 //
 // If SetWindowResizable is called with true and Run is used, SetWindowResizable panics. Use RunGame instead.
 //
+// SetWindowResizable does nothing on macOS when the window is fullscreened natively by the macOS desktop
+// instead of SetFullscreen(true).
+//
 // SetWindowResizable is concurrent-safe.
 func SetWindowResizable(resizable bool) {
 	theUIContext.setWindowResizable(resizable)
@@ -228,6 +234,9 @@ func IsWindowFloating() bool {
 //
 // SetWindowFloating does nothing on browsers or mobiles.
 //
+// SetWindowFloating does nothing on macOS when the window is fullscreened natively by the macOS desktop
+// instead of SetFullscreen(true).
+//
 // SetWindowFloating is concurrent-safe.
 func SetWindowFloating(float bool) {
 	if w := uiDriver().Window(); w != nil {